Publications

Publications

2024

Etesami NS, Barker KA, Shenoy AT, De Ana CL, Arafa EI, Grifno GN, Matschulat AM, Vannini ME, Pihl RMF, Breen MP, Soucy AM, Goltry WN, Ha CT, Betsuyaku H, Browning JL, Varelas X, Traber KE, Jones MR, Quinton LJ, Maglione PJ, Nia HT, Belkina AC, Mizgerd JP. B cells in the pneumococcus-infected lung are heterogeneous and require CD4+ T cell help including CD40L to become resident memory B cells. Front Immunol. 2024 Apr 23:15:1382638. doi: 10.3389/fimmu.2024.1382638. eCollection 2024.

Li Y, Han M, Singh S, Breckenridge HA, Kreger JE, Stroupe CC, Sawicky DA, Kuo S, Goldsmith AM, Ke F, Shenoy AT, Bentley JK, Matsumoto I, Hershenson MB. Tuft cells are required for a rhinovirus-induced asthma phenotype in immature mice. JCI Insight. 2024 Jan 23;9(2):e166136. doi: 10.1172/jci.insight.166136.

2023

Lyon De Ana C, Shenoy AT, Barker KA, Arafa EI, Etesami NS, Korkmaz FT, Soucy AM, Breen MP, Martin IMC, Tilton BR, Devarajan P, Crossland NA, Pihl RMF, Goltry WN, Belkina AC, Jones MR, Quinton LJ, Mizgerd JP. GL7 ligand expression defines a novel subset of CD4+ TRM cells in lungs recovered from pneumococcus. Mucosal Immunol. 2023 Aug 19:S1933-0219(23)00056-9. doi: 10.1016/j.mucimm.2023.07.004.

Iwanaga N, Devarajan P, and Shenoy AT*. Editorial: Adaptive immunity to respiratory pathogens. Front Immunol. 2023 Mar 6; 14:1174178. doi:10.3389/fimmu.2023. 1174178. eCollection 2023.

2022

Korkmaz FT, Shenoy AT, Symer EM, Baird LA, Odom CV, Arafa EI, Dimbo EL, Na E, Molina-Arocho W, Brudner M, Standiford TJ, Mehta JL, Sawamura T, Jones MR, Mizgerd JP, Traber KE, and Quinton LJ. Lectin-like oxidized low-density lipoprotein receptor 1 attenuates pneumonia-induced lung injury. JCI Insight. 2022 Dec 8;7(23):e149955. doi: 10.1172/jci.insight.149955.

Na E, Allen E, Baird LA, Odom CV, Korkmaz FT, Shenoy AT, Matschulat AM, Jones MR, Kotton DN, Mizgerd JP, Varelas X, Traber KE, and Quinton LJ. Epithelial LIF signaling limits apoptosis and lung injury during bacterial pneumonia. Am J Physiol Lung Cell Mol Physiol. 2022 Feb 9. doi: 10.1152/ ajplung.00325.2021. 

Arafa EI, Shenoy AT, Barker KA, Martin IMC, Korkmaz FT, Lyon De Ana C, Wooten AK, Belkina AC, Guillon A, Jones MR, Quinton LJ, Forsberg C, and Mizgerd JP. Recruitment and training of alveolar macrophages after pneumococcal pneumonia JCI Insight. 2022 Mar 8;7(5):e150239. doi: 10.1172/jci.insight.150239.

Shenoy AT*, Lyon De Ana C*, Barker KA, Arafa EI, Martin IMC, Mizgerd JP, and Belkina AC. CPHEN-011: Comprehensive phenotyping of murine lung resident lymphocytes after recovery from pneumococcal pneumonia. Cytometry A. 2022 Nov;101(11):892-902. doi: 10.1002/cyto.a.24522. Epub 2021 Dec 2. 

2021

Shenoy AT, Lyon De Ana C, Arafa EI, Salwig I, Barker KA, Korkmaz FT, Ramanujan A, Etesami NS, Martin IMC, Tilton BR, Hinds A, Goltry WN, Kathuria H, Braun T, Jones MR, Quinton LJ, Belkina AC, and Mizgerd JP. Antigen presentation by lung epithelial cells directs CD4+ TRM cell activities and regulates barrier immunity. Nat Commun. 2021 Oct 5;12(1):5834. doi: 10.1038/s41467-021-26045-w. *Invited for presentation at American Thoracic Society- Assembly of Allergy, Immunology & Inflammation- Journal Club*

Odom CV, Kim Y, Burgess C, Baird LA, Korkmaz FT, Na E, Shenoy AT, Arafa EI, Lam TT, Jones MR, Mizgerd JP, Traber KE, Quinton LJ. STAT3-dependent liver activity modulates the lung transcriptome and proteome to fortify pulmonary defense. J Immunol. 2021 Oct 1;207(7):1891-1902. doi: 10.4049/jimmunol.2100254. Epub 2021 Sep 1.

Barker KA, Etesami NS, Shenoy AT, Arafa EI, Lyon de Ana C, Smith NMS, Martin IMC, Barron AMS, Kepler TB, Browning JL, Kathuria H, Belkina AC, Guillon A, Zhong X, Jones MR, Quinton LJ, and Mizgerd JP. Lung resident memory B cells protect against bacterial pneumonia. J Clin Invest. 2021. Jun 1;131(11):141810. doi: 10.1172/JCI141810.

Traber K, Dimbo E, Shenoy AT, Symer E, Allen E, Mizgerd JP, and Quinton LJ. Neutrophil-derived Oncostatin M triggers diverse signaling pathways during pneumonia. Infect Immun. 2021 Feb 1; IAI.00655-20. doi: 10.1128/IAI.00655-20. Print 2021 Mar 17.

Shenoy AT, and Mizgerd JP. Resident memory lymphocytes contribute to unhealthy aging: seedy CD8s in older lungs. Cell Mol Immunol. 2021 Apr;18(4):787-789. doi: 10.1038/s41423-020-00629-w. Epub 2021 Jan 8.

2020

Wooten AK, Shenoy AT, Arafa EI, Akiyama H, Martin IMC, Jones MR, Quinton LJ, Gummuluru S, Bai G, Mizgerd JP. Unique Roles for Streptococcus pneumoniae Phosphodiesterase 2 in Cyclic di-AMP Catabolism and Macrophage Responses. Front Immunol. 2020 Mar 31;11:554. doi: 10.3389/fimmu.2020.00554.

Guillon A, Arafa EI, Barker KA, Belkina AC, Martin I, Shenoy AT, Wooten AK, Lyon De Ana C, Dai A, Labadorf A, Hernandez Escalante J, Dooms H, Blasco H, Traber KE, Jones MR, Quinton LJ, and Mizgerd JP. Pneumonia recovery reprograms the alveolar macrophage pool. JCI Insight. 2020. doi.org/10.1172/jci.insight.133042.

Beno SM, Riegler AN, Gilley RP, Brissac T, Wang Y, Kruckow KL, Jadapalli JK, Wright GM, Shenoy AT, Stoner SN, Restrepo MI, Deshane JS, Halade GV, Gonzalez-Juarbe N and Orihuela CJ. Necroptosis inhibition prevents long-term cardiac damage during pneumococcal pneumonia and invasive disease. J Infect Dis. 2020 Nov 9;222(11):1882-1893. doi: 10.1093/infdis/jiaa295.

Shenoy AT*, Wasserman GA*, Arafa EI, Wooten AK, Smith NMS, Martin IMC, Jones MR, Quinton LJ, and Mizgerd JP. Lung CD4+ resident memory T cells remodel epithelial responses to accelerate neutrophil recruitment during pneumonia. Mucosal Immunol. 2020 Mar;13(2):334-343. doi: 10.1038/s41385-019-0229-2.   *Recommended in F1000 Faculty Opinion*

2018

*Shenoy AT*, Beno SM*, Brissac T, Bell JW, Novak L, and Orihuela CJ. Severity and properties of cardiac damage caused by Streptococcus pneumoniae are strain dependent. PLoS One. 2018 Sep 14. 13(9): e0204032

2017

Brissac T, Shenoy AT, Patterson LA, Orihuela CJ. Cell invasion and pyruvate oxidase derived H2O2 are critical for Streptococcus pneumoniae mediated cardiomyocyte killing. Infect Immun. 2017 Oct 23. pii: IAI.00569-17. doi: 10.1128/IAI.00569-17.

Shenoy AT, Brissac T, Gilley RP, Kumar N, Gonzalez-Juarbe N, Wang Y, Hinkle WS, Daugherty SC, Shetty AC, Ott S, Tallon LJ, Deshane J, Tettelin H, and Orihuela CJ. Streptococcus pneumoniae in the heart subvert the host response through biofilm-mediated resident macrophage killing. PLoS Pathogens. 2017 Aug 25 ;13(8): doi: 10.1371/ journal. ppat.1006582

Spencer BL, Shenoy AT, Orihuela CJ, Nahm MH. The pneumococcal serotype 15C capsule is partially O-acetylated and allows limited evasion of PPV23-elicited anti-serotype 15B antibodies. Clin Vaccine Immunol. 2017 Jun 21. pii: CVI.00099-17. doi: 10.1128/CVI.00099-17.

Spencer BL, Saad JS, Shenoy AT, Orihuela CJ, Nahm MH. Position of O-acetylation within the capsular repeat unit impacts the biological properties of pneumococcal serotypes 33A and 33F. Infect Immun. 2017 Apr 24. pii: IAI.00132-17. doi: 10.1128/IAI.00132-17.

Lizcano A*, Akula Suresh Babu R*, Shenoy AT, Saville AM, Kumar N, D'Mello A, Hinojosa CA, Gilley RP, Segovia J, Mitchell TJ, Tettelin H, and Orihuela CJ. Transcriptional organization of psrP-secY2A2 and the impact of glycosyltransferase deletion on PsrP function. Microbes Infect. 2017 Apr 10. pii: S1286-4579(17)30043-6.

Gonzalez-Juarbe N, Bradley KM, Shenoy AT, Gilley RP, Reyes LF, Hinojosa CA, Restrepo MI, Dube PH, Bergman MA, Orihuela CJ.  Pore-forming toxin induced necroptosis is independent of death receptor signaling during bacterial pneumonia. Cell Death Differ. 2017 May;24(5):917-928. doi: 10.1038/cdd.2017.49.

Ray C, Shenoy AT, Orihuela CJ, Gonzalez-Juarbe N. Killing of Serratia marcescens biofilms with chloramphenicol. Ann Clin Microbiol Antimicrob. 2017 Mar 29;16(1):19. doi: 10.1186/s12941-017-0192-2.

2016

Reyes LF, Restrepo MI, Hinojosa CA, Soni NJ, Shenoy AT, Gilley RP, Gonzalez-Juarbe N, Noda JR, Winter VT, de la Garza MA, Shade RE, Coalson JJ, Giavedoni LD, Anzueto A, and Orihuela CJ. A non-human primate model of severe pneumococcal pneumonia. PLoS ONE. November 2016 11(11): e0166092. doi: 10.1371/journal.pone.0166092

Shenoy AT, and Orihuela CJ. Anatomical site-specific contributions of pneumococcal virulence determinants. Pneumonia 2016, 8:7 DOI: 10.1186/s41479-016-0007-9

Shenoy AT*, Blanchette KA*, Gilley RP, Milner II JD, McClure E, Hinojosa CA, Ferreira DM, King SJ, Gordon SB, Tettelin H, and Orihuela CJ. Neuraminidase A- exposed galactose promotes Streptococcus pneumoniae biofilm formation during colonization. Infect Immun. 2016 Sep 19;84(10):2922-32. doi: 10.1128/IAI.00277-16. Print 2016 Oct

Gilley RP, González-Juarbe N, Shenoy AT, Reyes LF, Dube PH, Restrepo MI, Orihuela CJ. Infiltrated macrophages die of pneumolysin- mediated necroptosis following pneumococcal myocardial invasion.  Infect Immun. 2016 Apr 22;84(5):1457-69. doi: 10.1128/IAI.00007-16.

Journal Cover Images

Shenoy AT, and Orihuela CJ. False-colored transmission electron micrograph of Streptococcus pneumoniae serotype 4 strain,TIGR4.   

Cover image of Clinical and Vaccine Immunology. April 2017, Volume 24, Issue 4